{"id":32229,"date":"2024-05-31T15:06:16","date_gmt":"2024-05-31T15:06:16","guid":{"rendered":"https:\/\/www.hri-research.org\/?p=32229"},"modified":"2024-11-09T09:24:51","modified_gmt":"2024-11-09T09:24:51","slug":"the-highest-level-of-scientific-evidence-supports-cost-effectiveness-of-homeopathy-a-finding-that-is-unchanged-by-a-recent-paper-by-leemhuis-seifert","status":"publish","type":"post","link":"https:\/\/www.hri-research.org\/sv\/2024\/05\/the-highest-level-of-scientific-evidence-supports-cost-effectiveness-of-homeopathy-a-finding-that-is-unchanged-by-a-recent-paper-by-leemhuis-seifert\/","title":{"rendered":"The highest level of scientific evidence supports cost-effectiveness of homeopathy \u2013 a finding that is unchanged by a recent paper by Leemhuis &#038; Seifert"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">A <a href=\"#\" class=\"definition\" title=\"Studies analysing the combined results of multiple similar trials to reach firmer conclusions\">systematic review<\/a><\/span><span style=\"font-weight: 400;\">\u00a0\u2013 considered the highest level of scientific evidence \u2013 was published in January 2024, providing an overview of cost-effectiveness studies of homeopathy<\/span><sup><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14737167.2023.2266136\"><span style=\"font-weight: 400;\">1<\/span><\/a><\/sup><span style=\"font-weight: 400;\">. <\/span><b>In all 21 studies included in this review<\/b><span style=\"font-weight: 400;\">,<\/span><b>\u00a0homeopathy showed similar or better clinical effectiveness compared to the control groups, with a clear positive trend for cost-effectiveness:<\/b><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-31627\" src=\"https:\/\/www.hri-research.org\/wp-content\/uploads\/2024\/04\/cost-effectiveness-table.png\" alt=\"\" width=\"1204\" height=\"278\" srcset=\"https:\/\/www.hri-research.org\/wp-content\/uploads\/2024\/04\/cost-effectiveness-table.png 1204w, https:\/\/www.hri-research.org\/wp-content\/uploads\/2024\/04\/cost-effectiveness-table-300x69.png 300w, https:\/\/www.hri-research.org\/wp-content\/uploads\/2024\/04\/cost-effectiveness-table-1024x236.png 1024w, https:\/\/www.hri-research.org\/wp-content\/uploads\/2024\/04\/cost-effectiveness-table-768x177.png 768w, https:\/\/www.hri-research.org\/wp-content\/uploads\/2024\/04\/cost-effectiveness-table-98x23.png 98w, https:\/\/www.hri-research.org\/wp-content\/uploads\/2024\/04\/cost-effectiveness-table-198x46.png 198w, https:\/\/www.hri-research.org\/wp-content\/uploads\/2024\/04\/cost-effectiveness-table-158x36.png 158w, https:\/\/www.hri-research.org\/wp-content\/uploads\/2024\/04\/cost-effectiveness-table-160x37.png 160w, https:\/\/www.hri-research.org\/wp-content\/uploads\/2024\/04\/cost-effectiveness-table-520x120.png 520w\" sizes=\"auto, (max-width: 1204px) 100vw, 1204px\" \/><br \/>\n<sup>*2 of these studies were shown to be cost-effective through <a href=\"#\" class=\"definition\" title=\"The \u2018incremental cost-effectiveness ratio\u2019 takes the difference in costs, divided by the difference in clinical outcomes, in order to make an overall comparison between two treatments.\">incremental cost effectiveness<\/a> analysis.<\/sup><\/p>\n<p><span style=\"font-weight: 400;\">The quality of the studies was assessed using the <a href=\"#\" class=\"definition\" title=\"Consensus Health Economic Criteria list\">CHEC<\/a><\/span><span style=\"font-weight: 400;\">\u00a0list<\/span><span style=\"font-weight: 400;\">, specifically designed for use with economic evaluations. CHEC scores\u00a0ranged from 2 to 16\u00a0(maximum score 19), with a statistically significant increase in study quality over the years (see <\/span><a href=\"https:\/\/www.hri-research.org\/resources\/homeopathy-faqs\/is-homeopathic-treatment-cost-effective\/\"><span style=\"font-weight: 400;\">HRI Cost-effectiveness FAQ<\/span><\/a><span style=\"font-weight: 400;\"> for further details).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lead author, Prof Thomas Ostermann of Universitat Witten\/Herdecke<\/span><span style=\"font-weight: 400;\">1<\/span><span style=\"font-weight: 400;\"> concluded that \u201c<\/span><i><span style=\"font-weight: 400;\">although the quality of research on homeopathy\u2019s cost-effectiveness has improved over time, and some high-quality studies show that it can be a cost-effective option, there are still many poorly conducted studies which make it difficult to offer a definitive statement<\/span><\/i><span style=\"font-weight: 400;\">.\u201d\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">We therefore read with interest a new paper by Leemhuis &amp; Seifert<\/span><sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38430230\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">2<\/span><\/a><\/sup><span style=\"font-weight: 400;\"> published in March 2024, titled, \u201cPrescriptions of homeopathic remedies at the expense of the German statutory health insurance from 1985 to 2021: scientific, legal and pharmacoeconomic analysis\u201d. However, regrettably, this study fails to meet basic scientific standards for a meaningful economic evaluation and, as such, adds nothing of value to the evidence base on this topic.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The quality of the study cannot be formally assessed using the CHEC-list tool, as it does not sufficiently resemble a true clinical cost effectiveness study<\/span><sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15921065\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">3<\/span><\/a><\/sup><span style=\"font-weight: 400;\"> (only 12 of the 19 checklist items could be assessed, with the study scoring 4\/12 for those items), but the fact that Leemhuis &amp; Seifert is a poorly conducted study is clear.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">An over-simplified approach was used to track the cost per daily dose of 16 homeopathic medicines prescribed by doctors in outpatient clinics and paid for through the German statutory health insurance (SHI) from 1985 to 2021.\u00a0 Using this crude data they concluded that homeopathy costs \u201c<\/span><i><span style=\"font-weight: 400;\">have continued to rise over the years<\/span><\/i><span style=\"font-weight: 400;\">\u201d. But the data were not adjusted for inflation or compared to changes in conventional medicine costs over the same time period.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Leemhuis &amp; Seifert also concluded that homeopathy was \u201c<\/span><i><span style=\"font-weight: 400;\">on average significantly more expensive<\/span><\/i><span style=\"font-weight: 400;\">\u201d than 9 selected alternative conventional medicines. However, <\/span><b>this claim is based on a subset of data<\/b> <b>monitoring homeopathic medicines during a single year only (2021) <\/b><span style=\"font-weight: 400;\">and is further weakened by the following issues:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The authors state that they found a \u201csignificant\u201d difference, yet no statistical analyses were performed\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The conventional medicines selected as comparators for each homeopathic medicine were poorly chosen e.g. homeopathic nasal decongestant spray <\/span><i><span style=\"font-weight: 400;\">Euphorbuim comp<\/span><\/i><span style=\"font-weight: 400;\">. was compared to ibuprofen and paracetamol tablets, instead of conventional nasal decongestant spray xylometazoline, used elsewhere in the study.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The authors failed to compare the clinical effectiveness of the \u2018matched\u2019 treatments \u2013 an essential step when considering the true value of any treatment.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">When attempting to apply this paper\u2019s findings to real world decision-making, further concerns arise. The homeopathic medicines tracked were prescribed for patients &lt;12 years, yet no consideration was given to the particular issues associated with treating such young patients. For the treatment of intestinal colic, Leemhuis &amp; Seifert<sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38430230\/\" target=\"_blank\" rel=\"noopener\">2<\/a><\/sup><\/span><span style=\"font-weight: 400;\">\u00a0compared a homeopathic suppository manufactured for <\/span><i><span style=\"font-weight: 400;\">babies<\/span><\/i><span style=\"font-weight: 400;\">, to the anti-spasmodic drug butylscopolamine, claiming it to be a \u2018rational\u2019 conventional alternative, even though <\/span><i><span style=\"font-weight: 400;\">this drug is contraindicated in children under the age of 6 years.<\/span><\/i><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Finally, the authors fail to mention that the overall cost of homeopathy on the SHI (in 2022) was only 0.01% of total drug expenditure<\/span><sup><a href=\"https:\/\/www.fakom.de\/missbrauch-von-wissenschaft-fuer-politische-desinformation\/#:~:text=BPI%20Pharma%2DDaten%202022%2C%20S.78\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">4<\/span><\/a><\/sup><span style=\"font-weight: 400;\"> \u2013 a figure which would have put their findings in appropriate context.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Given the extent of these shortcomings, and their obvious impact on the reliability of the study\u2019s conclusions, a Letter to the Editor is warranted to alert the journal to the poor quality of the paper. However, as the senior author of the paper, Prof Seifert, is himself the Editor-in-Chief of the journal which published his study, it is unlikely that this would prove worthwhile.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In conclusion, the paper by Leemhuis and Seifert<\/span><sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38430230\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">2<\/span><\/a> <\/sup>is misleading and of inadequate quality due to a collection of weaknesses, including use of an unknown, non-replicable method; failure to substantiate their key findings in a way that is compliant with EBM and selective citation.<sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39251199\/\" target=\"_blank\" rel=\"noopener\">5<\/a><\/sup><\/p>\n<p>The study therefore provides no useful insights into the likely cost and clinical effectiveness of homeopathic medicines, as prescribed by doctors in the German public health system. The systematic review by Ostermann et al.<sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37795998\/\" target=\"_blank\" rel=\"noopener\">1<\/a><\/sup> remains the most robust study on cost effectiveness to date, and the positive trends it identifies, based on studies from seven European countries<sup>6<\/sup>, supports the likely cost-effectiveness of homeopathy.<\/p>\n<p><b>References<\/b><\/p>\n<ol>\n<li><span style=\"font-weight: 400;\"> Ostermann T, Burkart J, de Jaegere S, Raak C, Simoens S. Overview and quality assessment of health economic evaluations for homeopathic therapy: an updated systematic review. <em>Expert Rev Pharmacoecon Outcomes Res<\/em> 2024;<strong>24<\/strong>:117-142 | <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37795998\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/span><\/li>\n<li><span style=\"font-weight: 400;\"> Leemhuis H and Seifert R. Prescriptions of homeopathic remedies at the expense of the German statutory health insurance from 1985 to 2021: scientific, legal and pharmacoeconomic analysis. <em>Naunyn Schmiedeberg\u2019s Arch Pharmacol<\/em> 2024: online ahead of print | <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38430230\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/span><\/li>\n<li><span style=\"font-weight: 400;\"> Evers S, et al. Criteria list for assessment of methodological quality of economic evaluations: Consensus on Health Economic Criteria. <em>Int J Technol Assess Health Care<\/em>, 2005;<strong>21(2)<\/strong>:240-5 | <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15921065\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/span><\/li>\n<li>BPI. Pharma-Daten 2022. Page 78. Available from: <a href=\"https:\/\/www.fakom.de\/missbrauch-von-wissenschaft-fuer-politische-desinformation\/#:~:text=BPI%20Pharma%2DDaten%202022%2C%20S.78\" target=\"_blank\" rel=\"noopener\">https:\/\/www.fakom.de\/missbrauch-von-wissenschaft-fuer-politische-desinformation\/#:~:text=BPI%20Pharma%2DDaten%202022%2C%20S.78<\/a><\/li>\n<li>Mosley AJ. Pharmacoeconomic Study of Homeopathic Medicines: A Critical Appraisal of Methods and Conclusions Shows Serious Cause for Concern. <em>Homeopathy 2024<\/em>; <strong>113(04)<\/strong>: 274-278<em> | <\/em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39251199\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a><\/li>\n<li>Source of studies included in Ostermann et al. 2024 review: Germany (n=8), UK (n=4), Italy (n=3), France (n=2), Switzerland (n=2), Belgium (n=1) and Netherlands (n=1).<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>A \u00a0\u2013 considered the highest level of scientific evidence \u2013 was published in January 2024, providing an overview of cost-effectiveness studies of homeopathy1. In all 21 studies included in this review,\u00a0homeopathy showed similar or better clinical effectiveness compared to the control groups, with a clear positive trend for cost-effectiveness: *2 of these studies were shown [&hellip;]<\/p>\n","protected":false},"author":835,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[12],"tags":[],"class_list":["post-32229","post","type-post","status-publish","format-standard","hentry","category-news"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.hri-research.org\/sv\/wp-json\/wp\/v2\/posts\/32229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hri-research.org\/sv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hri-research.org\/sv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hri-research.org\/sv\/wp-json\/wp\/v2\/users\/835"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hri-research.org\/sv\/wp-json\/wp\/v2\/comments?post=32229"}],"version-history":[{"count":0,"href":"https:\/\/www.hri-research.org\/sv\/wp-json\/wp\/v2\/posts\/32229\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.hri-research.org\/sv\/wp-json\/wp\/v2\/media?parent=32229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hri-research.org\/sv\/wp-json\/wp\/v2\/categories?post=32229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hri-research.org\/sv\/wp-json\/wp\/v2\/tags?post=32229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}